Projects
A modular storage and analysis pipeline for quality control, analysis and MAGE-ML export of microarray data
13 Jun 2005- 1 Jan 2009A rate-limiting step in applying microarrays is data handling. This includes extraction of raw signal intensities, quality control, experiment annotat…
Design and analysis of genetical genomics experiments
1 Jan 2005- 1 Oct 2010This project tackles the development of mathematical models, methods, algorithms and software for modern large-scale genetics experiments. The focus i…
Developing clinical predictors based on high-dimensional genomics data, pathway information and directed experimentation
1 Jan 2005- 1 Nov 2009In this project we develop statistical techniques that modify the gene selection strategy such that it takes particular known relationships between …
Experimental design, sample size determination and data analysis
1 Apr 2005- 31 Dec 2009This project aims to optimize the power of discovery in microarray studies, so that differentially expressed genes can be identified in a more cost ef…
Quantifying the association between multidimensional phenotypes and multidimensional genetic/genomic data
1 Sep 2005- 31 Dec 2009In this project bioinformatics tools are developed to (quantitatively) study the association between phenotypic variables, and genetic, genomic, or pr…
Understanding and reconstructing biological pathways
5 Apr 2005- 5 Jun 2011DNA microarrays are used to elucidate biological pathways. To visualize the expression data in a pathway context, the data can be linked to a pathway …
Unifying framework for data-driven pathway discovery
1 Jan 2004- 20 Sep 2009This project concentrates on the development of generic tools that enable the discovery of (evolutionary conserved) pathways by exploiting the various…