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Programme Wednesday April 20

08:30 - 09:00 Registration with coffee & tea
09:00 - 09:15 Opening by Lodewijk Wessels (to be confirmed)

G) Keynote session - Europazaal (Chair: Lodewijk Wessels)

09:15 - 10:00 Bas van Steensel, Netherlands Cancer Institute
  Chromatin domain organization of eukaryotic genomes

H) Parallel session Europazaal (Chair: Lodewijk Wessels)

10:00 - 10:20 Felipe Leal Valenin, Wageningen UR
  Quantitative modeling of the regulatory network of flowering time genes
10:20 - 10:40 Askar Obulkasim, VU University Medical Centre
  Stepwise Classification of Cancer Samples using Clinical and Molecular Data

I) Parallel session Aziezaal (Chair: to be announced)

10:00 - 10:20 Martijn Vermaat, Leiden University Medical Centre
  MUTALYZER 2: Improved Sequence Variant Descriptions from next generation
  sequencing data and locus-specific mutation databases
10:20 - 10:40 Lennart Karssen, Erasmus Medical Centre
  The GenABEL suite

J) Session Netherlands Society on Biomolecular Modelling (NSBM) - Videzaal

10:00 - 10:40 Chair: Gerry Nicolaes
  - Welcome by Gerry A.F. Nicolaes (NSBM)
  - Tina Ritschel, CDD Group, CMBI, Radboud UMC, Nijmegen
  Extraction of Useful Bioisostere Replacements from the PDB
  - Ezgi Karaca, Bijvoet Center for Biomolecular Research, Utrecht University
  A multi-domain flexible docking approach to deal with large conformational
  changes in the modeling of biomolecular complexes
10:40 - 11:10 Coffee & tea break
  Poster presentations

K) Parallel session - Europazaal (Chair: Lodewijk Wessels)

11:10 - 11:30 Maarten van Iterson, Leiden University Medical Centre
  An empirical method for finding mRNA targets of microRNA: improving
  sequence-based target prediction using expression data
11:30 - 11:50 Anton Feenstra, VU University Amsterdam
  Multi-Harmony: detecting functional specificity in HIV differential replication

L) Parallel session - Aziezaal (Chair: to be announced)

11:10 - 11:30 Gerard te Meerman, UMC Groningen
  A windows based suite for statistical analysis of next generation
  sequencing and its application to exome and RNA data
11:30 - 11:50 Kees van Bochove, NBIC
  A democracy of reporting standards of omics studies

M) Parallel NSBM session - Videzaal (Chair: Gerry Nicolaes)

11:10 - 11:50 - Barbara Zarzycka, Maastricht, Maastricht University
  Protein-peptide docking of human thrombin: towards improved imaging in
  cardiovascular disease
  - Albert Kooistra, VU University Amsterdam
  The agonism factor of ß1 and ß2 adrenergic receptors
12:00 - 14:00 Lunch buffet & poster sessions
  Application Showcase
  Poster presentations

N) Parallel session - Europazaal (Chair: Jaap Heringa)

14:00 - 14:20 Marc Hulsman, Delft University of Technology
  Ibidas: a bioinformatics-focused Problem Solving Environment for data
  exploration, accross various data structures and storage formats
14:20 - 14:40 Margherita Francescatto, VU University Medical Centre
  Profiling transcription initiation in human aged brain using deep-CAGE
14:40 - 15:00 Patrick Kemmeren, University Medical Centre Utrecht
  Simple network motifs provide the foundation of the yeast transcriptional

O) Parallel NSBM session - Videzaal (Chair: Gerry Nicolaes)

14:00 - 15:00 - Gert Vriend: Introduction to GPCR Modeling
  - Luc Roumen, VU University Amsterdam
  GPCR modelling at the Free University Amsterdam: the success of
  structural bioinformatics
  - Marijn Sanders, MSD, Oss & CDD group, CMBI, Radboud UMC Nijmegen
  A GPCR modeling pipeline: unbiased from low to high resolution
  GPCR complex models
15:00 - 15:30 Coffee & tea break
  Poster presentations

P) Plenary session - Europazaal (Chair: Jaap Heringa)

15:30 - 15:40 Irene Nooren, University of Amsterdam
  e-BioGrid: Enabling Life-Science Research and Technology
15:40 - 15:50 NBIC Hackathon results
15:50 - 16:20 Final application showcase
16:20 - 16:50 Award ceremony winner of the NBIC Young Investigator Award 2011
  followed by a lecture by the winner Dr. Yang Li
  Generalized Genetical Genomics -Advanced methods and applications

Q) Keynote session - Europazaal (Chair: Jaap Heringa)

16:50 - 17:35 Phil Bourne, Department of Pharmacology & Skaggs School
  of Pharmacy and Pharmaceutical Sciences, University of California San Diego
  Bioinformatics Meets Systems Biology for Early Stage Drug Discovery
17:35 - 18:00 Announcement of the winner of the application showcase &
  Poster prize winner & Best lecture prize winner &
  winner of the BIUP Poster Prize
18:00 Closing of the conference by Jaap Heringa